Gore Bio-Ahas been reported to be an ideal synthetic bioabsorbable scaffoldmaterial for hernia repair.The purpose of this studywas\nto determine the effectiveness of Gore Bio-A in soft tissue augmentation. SixNew Zealand white rabbits were used in the study. Five\nsubcutaneous pockets were created on the back of the rabbit, and 20Ã?â??20mm sized square shaped Gore Bio-A sheets, each 1.5 mm,\n3 mm, 4.5 mm, 6 mm, and 7.5mm in thickness, were implanted into each pocket (1 layer to 5 layers). To analyze the morphologic\nand histologic changes, the implants were harvested 1, 3, and 6 months after implantation. Following the gross analysis, absorption\nrate was accelerated with increased implant duration and decreased thickness. Histological analysis of the implants demonstrated\nprogressive neovascularization, fibroblast infiltration, and neocollagenation over time. Six months after implantation, Gore Bio-A\nwas almost absorbed and degenerated, notmaintaining its volume. Based on this study, Gore Bio-A was revealed as a biocompatible\nmaterial; however, it is not suitable for soft tissue augmentation because it is absorbed in the process of changing into soft tissue\nwithout maintaining its own volume. Therefore, this material is incomplete and needs more study to overcome this limitation.
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